There have now been 24.2 million confirmed cases of Covid-19 across the nation since the virus began to spread in February 2020.
The grim milestone is passed on the final day of the Trump administration and just over a month after the death toll hit 300,000.
It is expected that half a million people will have died from the virus by some point in mid-February.
President-elect Joe Biden will take the oath of office at midday on Wednesday and has readied a series of initiatives to try and thwart the spread of Covid-19.
Mr Biden intends to vaccinate 100 million Americans in his first 100 days in office with the help of the National Guard and FEMA, as well as instituting a federal mask mandate for interstate travel and public buildings.
The new president has also detailed a $1.9 trillion spending plan to tackle the economic impact of the pandemic.