Old Dominion 49, 13 Virginia Tech 35
Blake LaRussa came off the bench to throw for 495 yards and four touchdowns to lead the visiting Old Dominion to an upset of Virginia Tech.
LaRussa, who entered the game on Old Dominion’s second series, completed 30 of 49 and rushed for a touchdown to lead the 28½-point underdog Monarchs (1-3) to a stunning win over the Hokies (2-1) from the Atlantic Coast Conference.
Jeremy Cox’s 40-yard touchdown run with 1:34 remaining sealed the biggest win in program history. After the game, the Old Dominion faithful stormed the field.
The Hokies led 28-21 after a 72-yard touchdown pass from Josh Jackson to Damon Hazelton with 32 seconds left in the third quarter, but ODU scored on its next two possessions, taking a 35-28 lead on a 15-yard touchdown run by Cox with 9:57 to go — the Monarchs’ first lead of the game.
Things got worse for Virginia Tech, as Jackson went down with a lower leg injury on the first play of the ensuing drive. Backup quarterback Ryan Willis led the Hokies on a 75-yard march that ended with a 13-yard touchdown pass to Chris Cunningham with 7:15 remaining, tying the game at 35.
But the Hokies simply had no answer for ODU. LaRussa polished off a 75-yard drive with a beautiful 29-yard fade pattern to Jonathan Duhart for a touchdown with 5:11 left that was the game winner.
1 Alabama 45, 22 Texas A&M 23
Tua Tagovailoa passed for 387 yards and four touchdowns and ran for another score to lead host Alabama to a rout of Texas A&M.
The Crimson Tide (4-0) easily passed their first test against a ranked team. Kellen Mond and the Aggies (2-2) couldn’t put up nearly the fight they had in a 28-26 loss to No. 3 Clemson.
Tagovailoa completed 22 of 30 passes before leaving after Henry Ruggs III took a shuttle pass 57 yards for a score late in the third. His first attempt went for a 30-yard touchdown to a diving DeVonta Smith, and he hit the tight end Hale Hentges for two more scores. Damien Harris didn’t get many touches but had a 35-yard run and a 52-yard catch.
Mond completed 16 of 33 passes for 196 yards with a touchdown but was intercepted twice, including on his first throw. He collected 98 yards rushing despite getting sacked seven times.
Trayveon Williams, the Southeast Conference’s top rusher, found little room to run. He gained 31 yards on eight carries.
3 Clemson 49, Georgia Tech 21
Trevor Lawrence took a leading role in Clemson’s quarterback rotation, coming off the bench to throw four touchdown passes as the visiting Tigers produced their most complete performance of the season in a rout of Georgia Tech.
After the starter Kelly Bryant produced just 13 yards and one first down on Clemson’s first two possessions, Lawrence entered the game early in the second quarter. Lawrence, a native of nearby Cartersville, quickly guided the Tigers on a seven-play, 74-yard drive capped by a 17-yard touchdown pass to Hunter Renfrow that made it 14-0. Lawrence finished with 176 yards on 13-of-18 passing for the Tigers (4-0), also connecting with Justyn Ross for a 53-yard score, Travis Etienne on a 3-yard touchdown just before halftime and Tee Higgins for a 30-yard touchdown in the closing minutes.
It was a thoroughly dismal performance by Georgia Tech (1-3), which fumbled eight times, recovering seven of them but giving up a touchdown when Clelin Ferrell fell on a loose ball in the end zone for Clemson’s first touchdown. The Yellow Jackets completed just three passes and was held to 146 yards on the ground — not even close to its nation-high rushing average of 392.7 coming into the game.
4 Ohio State 49, Tulane 6
Dwayne Haskins Jr. threw for 304 yards and five touchdowns in the first half and Ohio State routed Tulane (1-3) to mark coach Urban Meyer’s return to the sideline following a three-game suspension.
Haskins was nearly flawless, completing his first nine passes on the way to a 21-for-24 effort before giving way to backup Tate Martell in the second half as the Buckeyes (4-0) backed off the gas and cruised. Haskins, a third-year sophomore, is among the nation’s leaders in touchdown passes with 16 through the first four games and is on track to eclipse J.T. Barrett’s school record of 35 set last season.
Meyer was back with his team after serving a suspension for his mismanagement of former assistant Zach Smith, who was accused of domestic violence and other questionable behavior while working under Meyer at Florida and Ohio State.
Meyer missed the blowouts of Oregon State and Rutgers, then sat in front of his TV nervously at home as the Buckeyes pulled away from then No. 15-TCU in the second half last week to win 40-28. Ryan Day, the co-offensive coordinator/quarterbacks coach, temporarily handled sideline coaching duties.
12 West Virginia 35, Kansas State 6
Will Grier threw five touchdown passes for the fifth time in his career and West Virginia shook off a sloppy start to drill Kansas State in the Big 12 opener for both teams.
Grier finished 25 of 35 for 356 yards and the five scores, three of them to David Sills, and two interceptions as the Mountaineers (3-0) had little trouble against the punchless Wildcats (2-2). Sills caught 10 passes for 73 yards and the three touchdowns. Marcus Simms added five receptions for 136 yards — including an 82-yard catch-and-run to open the scoring.
West Virginia outgained Kansas State 464-318, had four sacks and was never really threatened after getting it together late in the first half. Playing for the first time in two weeks after a visit to North Carolina State was canceled because of Hurricane Florence, the Mountaineers looked a bit off early. Each of their first two drives ended with turnovers.
Texas 31, 17 Texas Christian 16
Sam Ehlinger passed for two touchdowns and ran for a score, all in the second half, and host Texas ended a four-game losing streak to Texas Christian (2-2) with a Big 12 victory.
Texas (3-1) had been outscored 153-33 the last four years by Texas Christian and trailed 16-10 before the defense forced three turnovers by the quarterback Shawn Robinson in the third quarter.
The victory gives Texas its first three-game win streak since 2014. The Longhorns also have their first back-to-back wins over ranked opponents since winning three in a row in 2008, a run that vaulted Texas to No. 1 that season.
Ehlinger passed for 255 yards. Johnson finished with 124 yards on seven catches.
21 Miami 31, Florida International 17
N’Kosi Perry came off the bench to throw three touchdown passes, and Miami’s defense was airtight for most of the day in the host Hurricanes’ 31-17 victory over Florida International.
Travis Homer rushed 13 times for 114 yards and a touchdown, Lawrence Cager caught two scoring passes, and Miami held Florida Interational to 31 yards on its first 10 possessions. Brevin Jordan also had a touchdown catch for the Hurricanes (3-1), who lost the top receiver and returner Jeff Thomas in the first quarter for what was believed to be a cramping-related issue.
CJ Worton caught a pair of fourth-quarter touchdown passes from James Morgan for Florida International (2-2), which outscored Miami 17-0 and gained 139 of its 187 yards in the final 15 minutes.
8 Notre Dame 56, Wake Forest 27
Ian Book rushed for three touchdowns and threw for two more in his first start of the season, leading the visiting Fighting Irish (4-0) past Wake Forest. Book replaced Brandon Wimbush in the starting lineup and was 25 of 34 for 325 yards with touchdown passes covering 3 yards to Brock Wright and 7 yards to Chase Claypool, along with three short scoring runs.
Coach Brian Kelly said he made the switch because he was concerned that the offense’s struggles were starting to weigh on the other parts of the team. “I didn’t sleep great last night, because that’s a pretty big decision to make when you’re 3-0 and your quarterback that was leading your football team was 13-3 as a starter,” Kelly said. “But I had a lot of confidence in Ian and I thought our offense played to the level that it was capable of. That certainly showed itself today.”
Matt Colburn had a 2-yard touchdown run and Nick Sciba kicked two field goals for Wake Forest (2-2), which has lost two straight. Sam Hartman was 12 of 24 for 110 yards before he exited after taking a hard hit midway through the third.
2 Georgia 43, Missouri 29
Fueled by opportunistic defense and special teams early and a quick-strike passing game late, Georgia notched another victory against a divisional foe. Jake Fromm threw three second-half touchdown passes and the Bulldogs (4-0) returned a fumble and a blocked punt for scores to beat host Missouri.
The Bulldogs blanketed Missouri’s wide receivers, harassed its quarterback Drew Lock, and forced three turnovers in the first half against the seventh-best offense in the country entering the game. Lock, the highly touted N.F.L. prospect, completed 23 of 48 passes for 221 yards for the Tigers (3-1).
Missouri rushed for 172 yards, with Larry Rountree III, Damarea Crockett, Tyler Badie and Lock all scoring rushing touchdowns. Albert Okwuegbunam had nine catches for 81 yards. The Georgia cornerback Deandre Baker held Missouri’s leading receiver Emanuel Hall — who entered with 430 receiving yards — without a catch.
19 Michigan 56, Nebraska 10
Karan Higdon ran for 136 yards and a touchdown in the first half to help the Wolverines (3-1) build a huge lead as they coasted to a home victory.
In Coach Scott Frost’s last visit to Michigan two years ago, he said Central Florida “outhit” Michigan in a 51-14 loss. “We didn’t forget that,” Michigan’s Jon Runyan said. Michigan moved Nebraska around on offense, clearing huge holes for the running game and giving Shea Patterson plenty of time to throw. On defense, the Wolverines hit hard early and often, perhaps in part because the defensive coordinator Don Brown told them what Frost said after his last visit.
“We really took that to heart,” the Wolverines linebacker Devin Bush said. “And we wanted to make a statement.”
Mission accomplished. “We got whipped,” Frost acknowledged. The Wolverines led 20-0 after the first quarter and 39-0 at halftime.
The Cornhuskers (0-3) are off to their worst start since 1945.
Purdue 30, 23 Boston College 13
After three straight close losses to start the season, Purdue let off some steam on Boston College. Rondale Moore caught two touchdown passes and the Boilermakers had four interceptions while beating the visiting Eagles.
David Blough passed for 296 yards and three touchdowns for the Boilermakers (1-3), who had stumbled at the start of what was expected to be a promising season.
The Eagles (3-1) rolled in unbeaten and ranked for the first time in 10 years, but fell flat.
“Purdue played like a team with their back against the wall. They made plays they needed to make,” Boston College Coach Steve Adazzio said. Anthony Brown, coming off a career game with five touchdown passes, threw four interceptions. Star tailback A.J. Dillon was held to 59 yards on 19 carries by Purdue.
■ Tyree Jackson threw for 263 yards and three touchdowns and the visiting Bulls used their big-play offense to remain unbeaten and roll over the reeling Scarlet Knights 42-13. The win was Buffalo’s first over a Big Ten Conference opponent and pushed its record to 4-0.
■ Ronald Smith had seven catches for 113 yards a score and Chris Alleyne kicked three field goals to propel Columbia to a 23-15 victory over host Georgetown.
■ Jacob Dolegala threw for 168 yards and a pair of touchdowns, and Grant Ibeh’s interception return for a touchdown sealed Central Connecticut’s 24-13 defeat of Fordham.
■ Spencer Alston ran for 120 yards and a touchdown as visiting Yale defeated Cornell 30-24 in an Ivy League opener for both schools. Zane Dudek ran for two scores while Kurt Rawlings was 18-of-25 passing for 283 yards with Reed Klubnik making six catches for 100 yards for the Bulldogs (1-1).
■ Eric Dungey scored three touchdowns and threw for another to key a first-half blitz and host Syracuse continued its early season success with a 51-21 victory over former Big East rival Connecticut (1-3). Syracuse, which has not yet trailed this season, has won its first four games for the first time since 1991 and only the fourth time since the end of World War II.